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Choice B: CD28 is a costimulatory receptor constitutively expressed on naive T cells that interacts with B7 on antigen-presenting cells

2004;287:R772R779

Moreover, activated endothelial cells secrete cytokines and recruit monocytes through chemokine release

Confounding by indication is essentially assuming that the outcome observed is due to the exposure being studied even though it could be caused by the thing that indicated exposure to that thing