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Similarly, in the case of cigarette smoking, plasma GSH concentrations were significantly lower in smokers (1.81.3 M ) than in nonsmokers (2.41.0) and the resulting GSH/GSSG redox potential was significantly more oxidized (12818 mV vs

Circulating systemic serum glutathione appeared to be decreased in the old group compared to the young group, but the difference was not significance ( p -value: 0.1143)

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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later