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: Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

Silybum marianum powder was obtained from the local market

Reviews in Endocrine and Metabolic Disorders, 23(5), 979994

Interestingly, APAP is also metabolized in the kidney by deacetylation reaction in the presence of N-deacetylase enzyme into another severely toxic but minor metabolite, p-aminophenol