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Kizaki, S

ALK5 knockdown and its downstream pathway protected LUHMES cells from aSyn-induced toxicity To verify that the knockdown of ALK5 protected against aSyn-induced toxicity, we first validated whether the siPOOL siRNA against ALK5 could effectively and specifically reduce ALK5 mRNA expression

Activated glial cells release proinflammatory cytokines, such as interleukin1 (IL1) and tumor necrosis factoralpha (TNF), which exacerbate neuronal damage and synaptic loss (Heneka et al