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Preclinical Observations Findings observed in murine studies include: Endurance capacity: Increased treadmill running time and distance Mitochondrial function: Enhanced respiration and ATP production in muscle Cardiac metabolism: Improved fatty acid utilization in models of heart failure Renal function: Reduced mitochondrial dysfunction and inflammation in aging kidney models Metabolic profile: Improved glucose handling in metabolic syndrome models These results are limited to animal models using intraperitoneal injection

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Utilizing HPLCMS/MS, metabolic intermediates in the malateaspartate shuttle, urea cycle, glucosealanine cycle and beta-alanine, aspirate, and tryptophan breakdown pathways were found to differ significantly between controls and patients with ASD

266,267 Disruption of the CXXC5/DVL interaction ameliorates metabolic dysfunction and enhances the regenerative capacity in a Wnt/-catenin-dependent manner