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However, the success of maintenance therapy depends on the vulnerability of the treated tumor, its inability to develop cross-resistance mechanisms during the cytotoxic assault by the drug and conversely, the presence of robust defense mechanisms in healthy tissue to mitigate the drugs side effects

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These observations further suggest that there is increased systemic inflammation upon estrogen-deprivation in OVX animals as evident by the reversal of NO level in the OVX+E2 animal groups

Comparative effect of ANF and various diuretics on isolated nephron segments