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Furthermore, consistent with the immune-linked neurotoxicity/neuroprotection theory, this meta-analysis revealed elevated levels of quinolinic acid, which is strongly neurotoxic, and decreased levels of kynurenic acid, which is neuroprotective, in MDD patients with melancholic and psychotic features [135]

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The range of time that B12 injections can last will depend on factors like a persons metabolism and how often the injections occur