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Again, the metabolites identified above do not necessarily reflect the brains cellular processes in isolation, though BBB disruption, limited glymphatic [49] and passive transport to the periphery all increase after TBI [45]

Norman JG

2 Mitochondria dysfunction as primary damage post-traumatic brain injury Mitochondrial dysfunction refers to mitochondria failing to perform one of their critical functions: sensing, integration, or signaling (Picard and Shirihai, 2022)

In LPS-treated BV2 cells and rat primary microglia, UA inhibited the production of pro-inflammatory cytokines (e.g., NO, TNF-, and PGE2) to shield dopaminergic neurons from the toxic effects of activated microglia