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Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance

KA extensively reviewed the manuscript

Boghozian et al., 2023), which is prompted by a variety of signaling molecules, including fractalkine (Cao et al., 2019) and the purine, ATP (Davalos et al., 2005), extracellular peroxiredoxin (prx6) (Kuang et al., 2014), several Rho guanosine triphosphate hydrolyases (GTPases), like Rac, Cdc42, and Rho (Choi et al., 2011), CXCL12 (Huang et al., 2017), and apoptosis signal-regulating kinase 1 (ASK1) (Cheon et al., 2017)

This higher dosage makes Wegovy particularly effective for chronic weight management in adults