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in which vitamin D supplementation was given to 11,017 wellness program participants (average dose 6000 IU/day) with the goal of achieving a vitamin D level of at least 40 ng/ml (100 nmol/L)

Compared with other organs in the body, the brain consumes more oxygen, generates more free radicals, has a higher concentration of polyunsaturated fatty acids, and a lower level of antioxidants, and is therefore more susceptible to damage caused by oxidative stress ( Figure 1 Oxidative stress damage may be linked to schizophrenia mechanisms Social isolation, vitamin D deficiency, chronic stress during adolescence, perinatal infections, inflammation, etc.-all of which ultimately lead to oxidative stress ( Figure 2 )

Lichtenthaler HK (1996) Vegetation stress: an introduction to the stress concept in plants