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Arachidonic acid metabolism to prostaglandins by cyclooxygenase (COX) is a key for initiation of many inflammatory responses [3], [4]

The use of P5091 or P22077, two USP7 inhibitors, display a strong senolytic activity in several models of senescence 31

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Combined with the proliferation finding, it suggests the peptide may support DPC populations by both adding new cells and keeping existing ones alive longer