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In addition, some authors investigated the risk associated with serum UA levels in a large cohort of patients with tauopathies (including subgroups with progressive supranuclear palsy, AD, and frontotemporal dementia) [222]

In a study on C57BL/6J mice, lifelong supplementation with spermidine led to a significant extension of lifespan, with improvements in mitochondrial function, reduced oxidative stress and enhanced autophagic activity (Reference Eisenberg, Knauer and Schauer22)