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Furthermore, Tohada M Al-Noshokaty and colleagues found that selenium can overcome sorafenib resistance in thioacetamide (TAA) induced HCC in rats by modulation of mTOR, NF-B pathways and LncRNA-AF085935/GPC3 axis (100) ( Figure 2 )

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In the spleen of tumor-bearing mice, IL-12 and IFN- levels were also increased

In HT-1080 fibrosarcoma cells, 1% O 2 hypoxia increases FTH1 expression in an NCOA4-independently manner to inhibit RSL3-induced ferroptosis [110]