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Vina docking calculations are useful to predict the binding modes, orientations, and conformations of small molecule inhibitors within the catalytic domain of the target protein

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In vitro studies demonstrated that AOD-9604 promotes proteoglycan and collagen production in chondrocyte cultures

The problem of missing data is best handled by minimizing the number of subjects lost to follow up through various means such as trial design (e.g., continuing to collect data for participants even if they discontinue their randomized treatment), and providing guidance on statistical approaches to handling missing data [24, 25]