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269 BCAA uptake is dependent on the type I amino acid transporter LAT, and mutations in SLC7A5 and SLC3A2, members of the LAT family, impair BCAA uptake by T cells and inhibit the proliferation and differentiation of Th1, Th17, and CTL cells

At baseline levels, ROS support normal cellular functions, but when in excess, they can damage macromolecules such as lipids, DNA, and proteins (Sies, 2018), triggering cellular senescence