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A deeper meta-genomic insight to assure 3-D structure/function of nutrient molecules, priming/activation of nutrients with co-factors, compositional stoichiometry, optimal milieu (pH, redox, and ionic strengths), molecular interplay between bioactives (synergism/antagonism), target delivery, ADME/Safety/Toxicity profiles, and most importantly the bio-functional activity, are vital prerequisites in the development of nutrient-based remedials to RESET the virus-induced HMRD in long-COVID, the new onset global metabolic syndrome

[DOI] [PMC free article] [PubMed] [Google Scholar] [347].Beeram SR, Zheng X, Suh K, Hage DS, Characterization of solution-phase drug-protein interactions by ultrafast affinity extraction, Methods 146 (2018) 4657