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In MDD mice, high levels of reactive oxygen species (ROS) were found, which may be due to NADPH deficiency due to impaired PPP

ASHMI was determined to be safe and an effective alternative to prednisone, as ASHMI has no adverse effects on adrenal function and had a beneficial effect on the Th1 and Th2 balance [96]

After each injection, at the end of the run, the column was flushed with 100% phase B for 2 min, and then, the system was re-equilibrated to the initial isocratic conditions before the subsequent injection

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