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FGF21s effects on glycemic control and insulin sensitivity are likely mediated predominantly by FGFR1c signaling in adipose tissue, which should normally serve as one of the bodys main depots for excess calories in response to post-meal insulin

Evidence suggests that VSMC ferroptosis may help enhance atherosclerotic lesions

et al Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

While further research is needed to fully elucidate the mechanisms and long-term effects, this study provides strong evidence for the potential of intermittent fasting as an adjunct therapy in the management of rheumatoid arthritis, particularly in postmenopausal women who are overweight and obese