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This gene is related to glutathione peroxidase 7, where changes in enzyme activity may contribute to age-related macular degeneration (AMD) 31,32

In the mevalonate pathway, the enzyme 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, which converts HMG-CoA into mevalonate, is common to the biosynthetic pathways of both coenzyme Q 10 and cholesterol and is inhibited by statins (cholesterol-lowering drugs