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Furthermore, MD revealed decreased flexibility of p53 TAD2 in complex with FOXO4-DRI compared to the FOXO4 FH -bound state with RMSDs of 1 heteronuclear NOE data was recorded using the HSQCNOEF3GPSI bruker pulse sequence (32 scans, 256 points in F1, 1024 points in F2, 1278.772 Hz spectral width in F1, 9615.385 Hz spectral width in F2) using a three seconds saturation period

Additional outcomes included relative LF CFB at 48 wks and proportion of subjects achieving LF 85% of subjects

doi: 10.1074/jbc.M110.121327 55 HayanoMYangWSCornCKPaganoNCStockwellBR

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