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GLP-1 RAs and Ophthalmic Complications in Patients With Type 2 Diabetes

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IGF-1 directly activates satellite cells responsible for muscle fiber repair and growth

Known hypersensitivity Hypotension or uncorrected hypovolemia Increased intracranial pressure (head trauma) Inadequate cerebral circulation Constrictive pericarditis or pericardial tamponade Pharmacokinetics: The liver contains a high-capacity organic nitrate reductase that inactivates nitroglycerin, resulting in very low bioavailability (typically 65 yrs) subjects Lean body weight also affects its pharmacokinetics inversely Side Effects: Constipation Bradycardia AV conduction block Asystole Major drug interactions: Verapamil undergoes biotransformation by predominantly CYP3A4, however CYP1A2 and members of the CYP2C subfamily are involved in its metabolism Verapamil can produce additive effects with other antihypertensive drugs & with cardiac effects of beta blockers References: Bajwa ZH, Smith JH (2018): Preventive treatment of migraine in adults