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Methods: Study design: Multicentre cluster RCT with included health economic and process evaluations Study setting: Ambulance services, local stroke units and CSCs in England Cluster randomisation: Ambulance stations or teams Intervention: Specialist pre-hospital redirection pathway involving semi-structured telephone communication of information from ambulance to CSC clinicians, who then recommend admission destination according to the likelihood of treatable LVO being present Control: Standard care Study population: All suspected and confirmed stroke in participating regions Participant enrolment: Waiver of consent Co-primary outcome: Thrombectomy rate and time to treatment Secondary outcomes: Key aspects of emergency care including time intervals and receipt of other treatments including thrombolysis Sample size: Powered on a primary analysis population(ischaemic stroke), 564 thrombectomy procedures will detect at least 30-minutes difference in time to treatment

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Other Ingredients: Hypromellose (Natural Vegetable Capsule), Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate

104,105 Interventional therapy Interventional therapy, which causes ischemic necrosis of tumor tissue by blocking the blood supply to the tumor, has been used as a safe and effective treatment option for unresectable HCC