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One of the causes of cancer cells being more susceptible to high-dose VitC is their increased level of labile iron (Fe 2+ iron amenable to exchange between reactions), which reacts with H 2 O 2 to form the damaging hydroxyl radical (OH ) [224]

Bibi S, Kang Y, Du M, Zhu MJ

This greatly restricts the usage of native C3 protein for pharmacological inhibition of Rho-signalling in most cancer cells

There are four enzymes known to be involved in glutathione degradation, these include the Dug1 peptidase (Kaur et al., 2009) that cleaves the cys-gly peptide and the Dug2-Dug3 complex (Kaur et al., 2012), Ecm38p (-Glutamyl transpeptidase) (Kumar et al., 2003) and Gcg1p (Yeast Chac2) (Kaur et al., 2017