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Lysate-based systems suffered from batch-to-batch variation, hampering the ability to obtain consistent results ( More recently, a recombinant system called protein synthesis using recombinant elements (PURE) has been generated where all individual components required for transcription, translation, and energy regeneration are expressed, purified, and then reconstituted to create a cell-free system

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targeting cancer-specific isoforms (e.g., PKM2) or using nanocarriers could enhance specificity and reduce toxicity

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