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Additionally, skin irritation from polyphenols has been documented in some research, meaning that skincare products containing urolithin A may also have this risk.22 Finally, on the topic of pomegranate, since urolithin A is often derived from compounds of the fruit, it may interact with the same drugs (e.g., those metabolized by cytochrome P450, or CYP450, enzymes).23 24 These include but arent limited to:25 ACE inhibitors Blood pressure medications Statins (cholesterol-lowering medication) Warfarin (blood thinner) Sildenafil Anticonvulsants Sulfonylureas Buspirone (an anti-anxiety medication) Metformin Piracetam (a nootropic drug) Theophylline (used in asthma and COPD) However, Dr

[15] Oral supplementation is generally well-tolerated with minimal adverse effects, though absorption may remain suboptimal in some metformin users due to the ongoing interference with absorption mechanisms

Overall, there arent many data out there from strong clinical trials

Myers Cocktail $275 Named after the late doctor John Myers, this drip treatment is one of the most popular in the industry