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Though generally mild in children and adults, rubella poses devastating consequences in pregnancy, leading to congenital rubella syndrome (CRS), characterized by cataracts, deafness, cardiac anomalies, and neurologic impairment

Pharmacokinetic analysis revealed dose-proportional exposure and a half-life of approximately 56 days at doses of 6.3 mg/kg and above, with minimal accumulation, supporting a Q3W dosing schedule [69]

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On the other hand, E2 is also involved in the differentiation of diverse types of normal tissues, being critical to the generation of lobular-alveolar cells and the development of galactophorous ducts (Gompel et al., 2004)