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It is a reasonable precaution, not a strict requirement

Medicine has a long history of compounds that looked extraordinary in rodents, but failed or caused harm in people

10.1186/s13011-015-0006-5 49 Shankara-NarayanaN.YuC.SavkovicS.DesaiR.FennellC.TurnerL.et al (2020)

Nat Neurosci 12:393395 Durieux PF, Schiffmann SN, de Kerchove dExaerde A (2012) Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions