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How it works: Bitter orange is believed to encourage weight loss by increasing your basal metabolic rate or calories burned at rest therein stimulating fat breakdown and suppressing appetite ( Effectiveness: Though research has shown that synephrine increases the numbers of calories burned, its effect on weight loss is inconclusive ( Because bitter orange is often combined with other compounds such as caffeine in weight loss supplements, its difficult to interpret its effectiveness

It comes in several specialized formulations, each developed to address specific skin concerns and treatment areas

The CagriSema combination achieved over 20% weight loss in clinical trials - significantly more than either drug alone