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The following covariates were adjusted in the model: child sex, delivery type, parity, gestational age, birth weight, maternal age, maternal marital status, prenatal smoking, prenatal alcohol use, intrauterine inflammation, preeclampsia, diabetes mellitus, maternal stress, estimated cell-type proportions (CD4 + T cells, CD8 + T cells, B cells, monocytes, granulocytes, natural killer cells and nucleated red blood cells) and surrogate variables

10.1016/j.jconrel.2022.09.031 87 IsmailT.CalcabriniC.DiazA

These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

Disulfide bonds and free thiol groups in both proteins and smaller organic molecules like glutathione can 'trade places' through a disulfide exchange reaction