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Bortolato, M

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In states of copper overload, interventions that remove excess copper or restore normal cellular copper transport have shown promise in improving cardiac and mitochondrial function in preclinical studies [51]

As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer