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Metabolites 14 , 343 (2024)

Originally shown to bind only one SAM molecule per monomer, more recent ITC studies suggested a two-site model where a kinetically stabilising high-affinity SAM binding site would be formed from oligomerisation, while enzyme activation is driven by SAM binding to the lower affinity S2 site observed in dimeric CBS 516525 crystal structures 23,28,35

Although the expressions of p-JNK, pro-caspase-12 and CHOP were not upregulated, their potential involvement in regulation could not be ruled out

Additionally, it strengthens the skin barrier and improves hydration, making skin smoother and more resilient