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Although the presence of these enzymes in RBCs has been well documented, the relative contributions of each pathway have not been established

Potential interactions include: Metformin (used for type 2 diabetes) Proton pump inhibitors (PPIs) and H2-receptor antagonists (used for acid reflux) Colchicine (used for gout) Nitrous oxide (anaesthetic gas that can inactivate B12) Chloramphenicol (may reduce the haematological response to B12 therapy) If you take any of these medications long-term, discuss B12 monitoring with your healthcare provider

Hcy and folate metabolism are both parts of the one-carbon cycle, and because of this, they are closely related