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Some cases received immunotherapy early because the presentation appeared autoimmune, only for neurosyphilis to later emerge as the unifying diagnosis and antimicrobial therapy to become decisive ( Discussion Three scenarios: mimic, overlap, and trigger These observations support an infectionautoimmunity interface rather than a strict dichotomy (Table 1)

The Insulin-like growth factor 1 receptor (IGF-1R), one of the most intensely investigated kinase targets, is neither mutated in cancers nor did the clinical trials use a molecular-profile based stratification of patients

Furthermore, the expansion of pathobionts like Peptostreptococcus can generate detrimental metabolites (e.g., indole derivatives), which directly upregulate cartilage-degrading MMP-13 (2628)

Winblad B, Giacobini E, Frlich L, Friedhoff LT, Bruinsma G, Becker RE, et al