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Description

A pivotal 2007 study published in the Journal of Physiology and Pharmacology examined rats with experimentally induced esophagitis and sphincter failure

Accessed August 19, 2020

Remarkably, as seen in Fig 6D, the HP-INHIB-4488 inhibitor led to up-regulation of proinflammatory genes over the reference control, specifically at the basal (nonstarved) conditions and at 4 and 24 h of starvation, whereas the expression of ER stressassociated genes was up-regulated mostly at 24 h