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In studies combining NNMTi with other weightloss drugs, coadministration with GLP1 receptor agonists significantly enhances weightloss efficacy while reducing side effects such as nausea and vomiting commonly associated with GLP1 agonists

Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, et al

Potential interactions with drugs metabolized by methyltransferases should be considered

As IDD is extremely common, and with its substantial impact on disease burden in terms of lower back pain, numerous animal models have been developed in an effort to further understand and explore treatment options for this condition