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Aquat Toxicol 80:290297 Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry based metabolomics

Further evidence indicates that microbial dysbiosis exacerbates renal inflammation and accelerates the progression of HN by impairing intestinal barrier integrity and increasing permeability, thereby facilitating the translocation of harmful metabolites, such as pro-inflammatory cytokines and uremic toxins, into the systemic circulation ( Figure 2 ) [152, 153]

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