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Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression

L., Zenk, J., Kuskowski, M., Ward, L., & Bastian, E

35 , 633650.e639 (2023)

Within this pathological network, mtROS and NLRP3 inflammasome activation form a critical molecular hub: mitochondrial dysfunction induces complexes I and III of the electron transport chain to generate large amounts of mtROS, which triggers NLRP3 inflammasome activation through pathways such as promoting the binding of TXNIP to NLRP3, releasing oxidized mitochondrial DNA (ox-mtDNA) as a co-activator, and modulating mitochondrial membrane potential