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It was confirmed that the multidirectional positive role of ALC in the dopaminergic system [20] depended on the slowing down of the progressive deterioration of dopaminergic receptors with a simultaneous increase in the concentrations of dopamine (a neurotransmitter responsible for mood, processes of thinking, the coordination of movement and resistance to stress) in neurons [83]

As the degree of ischemia worsens, patients may experience paresthesias, coldness of the extremity, muscular weakness, and stiffness of the foot and ankle joints

*Correspondence: Zhenguo Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Low white blood cell and/or platelet counts highest risk at 7-10 days after treatment