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In addition, in a rat renal ischemiareperfusion injury model, bardoxolone methyl decreased urea, creatinine, NGAL, total oxidant status, nitric oxide, and ADMA levels, increased SOD and GSH-Px activities, and upregulated renal Nrf2 and PPAR expression, suggesting that its anti-oxidative, anti-inflammatory, and anti-apoptotic effects collectively mitigate AKI severity (258)

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Patients receiving systemic treatment for acute lymphoblastic leukemia are at high risk for developing febrile neutropenia , a life-threatening complication defined by an absolute neutrophil count of less than 500/mm 3