glutathione reduces toxicity of epoxides The Key Role GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates Glutathione-Mediated Conjugation of Anticancer Drugs

Yokoyama S

Which one is better

doi: 10.1016/j.jncc.2025.01.007 Summary Keywords colorectal cancer, microsatellite stable, antibody-drug conjugate, immunoconjugate, immuno-oncology Citation Wang Y, Lu K, Xu Y, Xu S, Chu H and Fang X (2025) Antibody-drug conjugates as immuno-oncology agents in colorectal cancer: targets, payloads, and therapeutic synergies

Protects Skin from Aging and UV Damage Ergothioneine builds up in skin cells through the OCTN-1 transporter and helps counter several key drivers of skin aging: Sun damage: Absorbs UV light and helps prevent UV-triggered DNA damage [14] Collagen loss: Inhibits MMP-1, the enzyme that breaks down collagen [15] Uneven tone: Clinical data show reduced wrinkles, age spots, and hyperpigmentation by suppressing excess melanin [15] Loss of firmness: Protects collagen and elastin and supports better hydration and elasticity [15] Inflammation: Its anti-inflammatory properties help calm acne, rosacea, psoriasis, and atopic dermatitis, and in some models it outperforms coenzyme Q10 and vitamin C against free radicals [15] These benefits have been observed with both topical ergothioneine and oral supplementation