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[151] During the 1920s, George Whipple discovered that ingesting large amounts of liver seemed to most rapidly cure the anemia of blood loss in dogs, and hypothesized that eating liver might treat pernicious anemia

These anti-inflammatory effects occurred without significant changes in serum nitrite/nitrate concentrations, which were elevated in arthritic rats

and 4: strong generalized irregularity of the diameter of the blood vessels with severe atrophy of the optic disc, barely visible (extremely faint presentation) choroidal blood vessels (bright fundus background color)