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Moreover, splenic white pulp was also noted to contain a lowered relative number and volume of lymphoid follicles, and a decreased number of Bcl-6+ B cell-containing germinal centers (73)

The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)

Deficiency can lead to conditions like inflammation, cancer, diabetes, and neurodegenerative diseases

, triple board certified in internal medicine, medical nutrition, and obesity medicine, and chief medical officer at Lindora Clinic