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Briefly, after RNA extraction, purification and library construction, these libraries were sequenced using Next-Generation Sequencing technology based on Illumina HiSeq sequencing platform with double-end (Paired-end, PE), and then the raw downstream data (Raw Data) were filtered

Rather than targeting a single pathway, this peptide combination activates multiple interconnected signaling networks across incretin and amylin receptor systems that collectively enhance metabolic responses beyond what individual components might achieve alone

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Cagrilintide is engineered around that problem: it is a modified, lipidated peptide that acts as a dual amylin and calcitonin receptor agonist and is stable enough for once-weekly subcutaneous dosing