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The sequence itself, this 12 nucleotide sequence, can determine to some degree whether it's going to be activated or turned off

For example, glutamate plays a key role in a series of reactions called the -glutamyl cycle

KYN levels were elevated (~ 2.1-fold), and TDO expression (both glial density and intensity in grey and white matter) was significantly higher, suggesting that enhanced KP metabolism may contribute to psychotic features in bipolar disorder