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Recent advancements in neuropharmacology have intensified the search for multi-targeted therapeutic agents, particularly plant-derived compounds that exhibit neuroprotective, anti-inflammatory, and antioxidant properties (Papadopoulou et al., 2024)

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2.9 Seahorse XF Mito Stress Test assay MEC-1 and HG-3 cells were seeded at a density of 1 10 6 cells/mL and incubated for 24 hours with DMSO and CB-839 at equitoxic concentrations based on the IC 50 values established during the MTS assay

Since ML171 is structurally related to some commonly used phenothiazine-derived anti-psychotic drugs (e.g., chlorpromazine), it may interfere with receptors for serotonin and adrenaline (Altenhfer et al., 2015