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Blackwell Publishing, Oxford, UK, pp 156173

However, when the detoxifying system fails due to a reduction in glyoxalase activity or GSH deficiency, MG and advanced glycation end-products (AGEs) formation increases, but D-lactate levels can be reduced, as has been observed in endothelial cells ( Methylglyoxal promotes glycation on lipids, nucleic acid and proteins (Rabbani and Thornalley, 2012)