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Hughes KC, Gao X, Kim IY, Rimm EB, Wang M, Weisskopf MG, Schwarzschild MA, Ascherio A (2016) Intake of antioxidant vitamins and risk of Parkinsons disease

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The main obstacle in delivering antioxidants to the anterior segment through topical application lies in the unique structure of the ocular surface, including the dense corneal epithelial barrier and the rapid turnover of the tear film [14, 15]

Mitochondria-targeted monofunctional platinum complexes can accumulate in the mitochondria, induce significant changes in mitochondrial ultrastructure and membrane, release cytochrome c(Cytc) from mitochondria, and disrupt mitochondrial OXPHOS and glycolysis (118)