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In following sections, we provide a comprehensive analysis of the fundamental knowledge on immunosuppressive TME modulating antitumor immune response, various resistance mechanisms to current immunotherapy, and advance strategies to prevent distinct challenges in the treatment of HGGs and BM

Efficacy and safety of antidepressants in patients with comorbid depression and medical diseases: an umbrella systematic review and meta-analysis

Xu X-M, Sansores-Garcia L, Chen X-M, Matijevic-Aleksic N, Du M, Wu KK (1999) Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate

Combined treatment of melatonin and erastin markedly reduced the tumor size in vivo, demonstrated no obvious systemic side effects, and significantly enhanced the apoptosis and ferroptosis levels in the tumor tissues, in parallel with decreased autophagy levels