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Summary Keywords organoid, 3D cultures, spheroids, mitochondrial diseases, neurodevelopmental disorders, high-throughput screening, drug repurposing Citation Coronel R, Garca-Moreno E, Siendones E, Barrero MJ, Martnez-Delgado B, Santos-Ocaa C, Liste I and Cascajo-Almenara MV (2024) Brain organoid as a model to study the role of mitochondria in neurodevelopmental disorders: achievements and weaknesses