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Daratumumab is also approved in combination with bortezomib-melphalan-prednisone, bortezomib-thalidomide-dexamethasone, or lenalidomide-dexamethasone in newly diagnosed MM (NDMM), based on the ALCYONE, CASSIOPEIA, and MAIA trials, respectively, and in combination with bortezomib-cyclophosphamide-dexamethasone for light-chain amyloidosis, based on the ANDROMEDA trial [13, 14, 17, 18]